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Summary

  • Photochemical internalisation can improve the delivery of genes, oligonucleotides, proteins, nanomedicines and some small molecule drugs.
  • In vivo, this improvement only takes place in illuminated areas of the body, so that adverse effects due to the activity of drugs in non-target areas may be greatly reduced.
  • PCI can be combined with most other means for obtaining specific drug delivery or actions, such as receptor/antigen targeted drug delivery, tissue/disease-specific gene promoters, disease-specific drug action and so on, generally adding to the efficiency and specificity of in vivo therapy.
  • PCI has wide applications as a drug delivery technology.